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In addition to KEAP1, which is the main negative regulator of NRF2 protein stability, many other factors which negatively regulate NRF2 have been discovered and characterized

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Interaction between p53 N terminus and core domain regulates specific and nonspecific DNA binding

[DOI] [PMC free article] [PubMed] [Google Scholar] 82.Sharifudin S.A., Fakurazi S., Hidayat M.T., Hairuszah I., Aris Mohd Moklas M., Arulselvan P

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Always in rats, continuous light exposure led to diminished humoral responses and interleukin-2 (IL-2) secretion, as well as persistent disruption of circadian leukocyte rhythms and decreased number and activation of NK cells 90,91